How many grounds do you think you need?
The OP is not wanting to run a extra 60-100 Amps through the car body.
Trying to minimize drilling holes in body if avoidable
You want to use the frame for ground. With this in mind my suggestion would be only one hole.
Pick a spot on the rear frame for a ground cable. Then pick a spot to drill through the trunk sheet metal.
Make a sandwich. Bolt, ground lug from frame cable, car sheet metal, lug from ground cable to amp, and a locking nut.
I can not help with a best location.
The enemy of this method is the ground lugs rusting and not conducting. The best is to use copper anti-seize or di-electric grease (silicone) to prevent salt and air getting between metal layers, and painting over the bolt, lug, and frame or body metal to stop the rust.